Sentence examples for alterations in the regulatory from inspiring English sources
Our results demonstrate alterations in the regulatory pathway that controls PGC-1α expression and induction of Mfn2 in muscle from patients with early-onset type 2 diabetes.
Therefore, attention is turning to potential mechanisms of aberrant Rho activation, such as alterations in the regulatory proteins or aberrant growth factor stimulation.
We now wondered whether the other seven risk genotypes in the model would contribute to alterations in the regulatory microenvironment, for example, the microRNAome.
Alterations in the regulatory mechanisms of apoptosis are, therefore, responsible not only for the progression of breast cancer, but for different response to treatment as well [ 7].
Since the 1635 G>A SNP at the TLR9 gene causes a synonymous amino acid change but no alterations in the regulatory site, it was suggested that other polymorphisms might affect the immune response against T. gondii as well [ 14].
This slight alteration in the regulatory protein, LeMYC2, level in transgenic lines might have attributed to significant changes in the target gene expression.
In this situation, protein production is either inhibited or it occurs at an inappropriate time because of alterations somewhere in the regulatory region.
Furthermore, it was investigated whether gallstone disease is associated with alterations in the major regulatory transcription factors of the sterol transporters as summarized in Table 3.
Similarly, topological alterations in the transcription regulatory network that are generated under specific conditions of cell activation have also been mapped [ 9].
Thus, elucidating possible alterations in these regulatory processes e.g. altered expression of steroidoigenic enzymes, may warrant future detailed investigations.
Our present study identifies PD-1 as a crucial factor regulating tissue homeostasis of T-lymphocytes and indicates that a primary oligodendropathy combined with alterations in this regulatory pathway can lead to accelerated neuroinflammatory reactions of high pathogenetic impact.
