The phrase "alterations in the developing" is not correct and lacks clarity in written English.
It may be intended to refer to changes occurring during a developmental process, but it is incomplete and ambiguous.
Example: "The researchers observed alterations in the developing brain of the subjects."
Alternatives: "changes in the development" or "modifications during development".
5 8 Proposed pathophysiological mechanisms underlying asthma development include alterations in the developing immune system 9 which may be affected by maternal corticosteroid intake.
Very early life pain exposure and stress induces alterations in the developing brain and leads to altered pain sensitivity.
Underlying the differences in neonatal and adult sepsis are alterations in the developing immune system.
HI insult leads to acute alterations in the developing cortex with long-term micro-architectural alterations that are reflected by changes in cortical DTI-derived parameters.
Each paradigm facilitates investigation into ELS-induced alterations in the developing animal and centres on the importance of mother for normal nervous, immune and endocrine system development [ 40– 40].
Therefore, both greater follicular recruitment and longer AGD in adulthood - assuming that AGD is a stable finding in humans throughout their lives - may reflect a common origin in utero, resulting in alterations of the developing female reproductive tract.
This suggests that addictive use of Internet games may result in functional alteration of the developing brain in adolescents.
In a recent pair of studies, we found that perinatal ETS exposure in rhesus monkeys elicits alterations in cell signaling in the developing brain akin to those identified for nicotine administration in rodents, including the up-regulation of nicotinic cholinergic receptors, a characteristic of chronic nicotine-induced neuronal stimulation (Slotkin et al. 2000, 2002).
For alteration of Shh pathway in the developing mouse cerebellum, P0 animals were given a daily dose of Cyclopamine (Chen et al., 2002a) or Smoothened Agonist (SAG) (Chen et al., 2002b) for 6 days, starting at P0. Cyclopamine (ALX-430-159-M005; Alexis, FarmiNYdale, NY, USA) was dissolved in 100% ethanol and injected subcutaneously at 10 µg/g body weight.
Although analysis of heterozygous EXT1-deficient mice has failed to reveal any significant gross morphological variations in skeletal development, significant alterations in molecular signaling occur in the developing long bones.
While the direct mechanisms of neurodevelopmental toxicity have not been fully elucidated, it is conceivable that alterations in thyroid hormone levels in the developing brain may contribute to these effects.
