Sentence examples for alterations in the course of from inspiring English sources

The sexual makeup of an entire oyster population also has a seasonal aspect; in harmony with the group, an individual may undergo several alterations in the course of a year.

Morphologic changes were not restricted to senescent stages but represented continuous alterations in the course of long-term culture of MSC.

This inheritance of epigenetic modifications might provide an ideal mechanism for the regulation of progressive alterations in the course of aging [4].

These data indicate that DC apoptosis occurs early in sepsis, and prompted us to assess functional DC alterations in the course of sepsis.

Aetiological role of papillomaviruses in cervical cancer is established while the role of cellular gene alterations in the course of tumor progression is less clear.

In this study, we used Cancer Array-800 and compared copy-number aberrations between lung AIS (Noguchi Type A or B) and early-invasive adenocarcinoma of the lung (Noguchi Type D or E) to find early genetic alterations in the course of malignant progression of lung adenocarcinoma.

The response after combination therapy was monitored on the basis of alteration in the course of parasitaemia, the extension of mean survival time and the percent cure rate in different groups.

Morphological alteration in the course of tumor progression has been studied in the early stage of carcinogenesis, as in adenoma carcinoma sequences and de novo cancer.

Indeed, diabetic cardiomyopathy is currently defined in terms of diastolic dysfunction, which is the earliest functional alteration in the course of diabetic cardiomyopathy [ 5- 8].

Diabetic cardiomyopathy is currently defined as a diastolic dysfunction, and several studies of DM patients have identified LV diastolic dysfunction as the earliest functional alteration in the course of diabetic cardiomyopathy [ 5- 9], and also established it as an important prognostic parameter [ 6].

We show for the first time that muscle tissue suffers metabolic alterations early in the course of disease development, alterations that influence the course of the pathology.