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As in zebrafish, alterations in the clock period were observed after disrupting Notch signalling in the mouse [ 90].
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Our studies however identify alterations in the Arabidopsis clock after the cold-exposure period.
Since the clock shift was not de-coupled from the sleep loss, two conclusions are possible: alterations in the molecular circadian clock affected glycogen stores, or the sleep loss in combination with changes in the molecular circadian clock affected glycogen.
We hypothesize that some of the prenatal effects of cocaine might be related to dysregulation of physiological rhythms due to alterations in the integrating circadian clock function.
Our results highlighted a programming of alteration in the circadian clock by the early diet that may have influenced the blood pressure.
Alteration in the circadian clock genes expression, regardless up- or down-regulation, breaks the balance of cell division and results in proliferation of tumor cells.
Hence, it is likely, that alterations in core clock components involved in the interpretation of the light signal are the underlying reason for the observed PRC in Rev-Erbα−/−Per1Brdm1 double mutants (Fig. 4A, 4C).
Alterations in the integrating role of the clock system would result in mutual de-synchronization of internal physiological processes and lack of coordination with the external, including maternal, environment.
The circadian behavioral phenotype of HAB mice is associated with specific alterations in clock gene expression in the hippocampus.
Alterations in the ELF3-Sha oscillator and clock resetting.
We ascribed their behavior to alterations in other clock properties like amplitude [13].
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