Sentence examples for alterations in specific from inspiring English sources

When tumor progression requires alterations in specific oncogenes (oncogene addiction), drugs that selectively block their products might slow tumor growth.

Neuroreceptor ligands applicable to PET imaging could provide tools to investigate alterations in specific neurotransmissions under pathological conditions and to quantify the receptor occupancy by therapeutic agents.

This method allows identifying individuals in whom symptoms are explained by preceding alterations in specific stress biomarkers, based on time series of symptoms and stress biomarkers.

Native polyacrylamide gel electrophoresis (PAGE) of SOD, CAT and POD also displayed increased enzymatic activity along with associated alterations in specific isoforms.

Of these, aCGH is highly useful to detect copy-number variations (CNVs) in the genome of individuals with apparently normal karyotypes [5,6], and MLPA can identify various copy-number alterations in specific disease-associated loci [7].

This study was designed to evaluate (i) whether individual variability in behavioural reactivity to novelty could be related to a differential vulnerability to show spatial learning deficits after chronic stress in young adult rats, and (ii) to what extent, could individual differences in stress-induced cognitive alterations be related to alterations in specific neurobiological substrates.

Moreover, several studies have identified alterations in specific PP2A subunits in human cancers, which has led to the hypothesis that PP2A serves as a tumor suppressor [6], [7].

Overall, it is clear that the lack of gross changes in in vivo protein dynamics must obscure critical alterations in specific protein formation, such that combing protein measurements with global transcriptomics provides a powerful solution to understanding the nature of tissue remodelling in multiple organ failure patients.

Alterations in specific nucleotides within the 23S rRNA lead to decreased affinity between drug and ribosome.

Alteration in specific components of the PI3K signaling pathway, such as PDK1, leads to an impaired transition from DN to DP thymocytes, suggesting an essential role of factors downstream of PDK1 in T cell development.

While Dex-induced muscle atrophy selectively affects fast fibers, there are no gross changes in architecture which may explain the lack of alteration in specific force.