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Undocumented design changes: During implementation, project staff may introduce alterations in project design and intended outcomes that they believe are necessary accommodations to get past unanticipated hurdles or design oversights.
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The ban on hormone-altering alterations in baby bottles.
Kearney et al. (2009) used a biophysical model in conjunction with an evolutionary response component to project alterations in the range of Ae. aegypti in Australia due to climate change and concluded that habitat for the mosquito will likely expand as individuals increase household water storage in response to a drier climate.
Bartholdi made alterations in the design as the project evolved.
Single-cell genomics allows CaST investigators, particularly in Project 2, to identify genetic alterations that co-occur or occur exclusively in specific subpopulations of cancer cells.
Landmark studies contributing to these projects have revealed alterations in cell signaling cascades that vary between cancer types and within tumors themselves.
Somatic copy number alterations in frequently observed segments in the TCGA project.
The Yale Pathophysiology of Type 2 Diabetes in Obese Youth Study is a long-term project that examines early alterations in glucose metabolism in obese children and adolescents.
The project is cataloging the genetic alterations in 33 cancers.
Somatic copy number alterations in 22 druggable targets reported in the TCGA project.
For example, the TCGA GBM project has cataloged somatic mutations and recurrent copy number alterations in GBM, and has identified frequent alterations in the p53, RB, PI3-kinase (PI3K) and receptor tyrosine kinase (RTK) signaling pathways [4].
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