Sentence examples for alterations in programs from inspiring English sources

Collectively, these results demonstrate major alterations in programs controlling cell proliferation and signal transduction, together with pathways regulating specific cellular stress, cell death, cell cycle and metabolic responses that may modulate the cellular phenotypes associated with TIA1 overexpression.

We imagine that in a given cell type, if the silencing of an undesirable activator or repressor is imperfect, their specific interacting partners in the targeted core machinery may nevertheless not be present, thus serving as a fail safe mechanism to prevent unscheduled alterations in programs of gene transcription.

Examples include medical insurance programs for the elderly, disabled, and poor; alterations in health programs to contain costs; occupational safety regulations; and regulation of environmental hazards.

New therapies are required to block the limitless self-renewal properties of leukemic progenitor cells associated with alterations in transcriptional programs.

Focal events are then followed by tumorigenic alterations in transcription programs, which further affect downstream gene expression patterns.

Hematopoiesis is one of the best-understood developmental pathways and involves dynamic alterations in transcriptional programs, which regulate progression along the differentiation hierarchy (Pimanda and Göttgens, 2010).

Elucidating the full transcriptional programs that control cilium number and diversification will also help us to understand and hopefully treat the many distinct ciliopathies that result from alterations in these programs.

These findings point out that a splicing factor such as SPF45 may be regulated by multiple MAP kinase pathways which can result in alterations in splicing programs relevant to cancer cells.

During prostatic carcinogenesis, periepithelial stroma undergoes progressive loss of smooth muscle accompanied by the appearance of CAFs, either through alterations in differentiation programs of smooth muscle cells or by recruitment of fibroblasts to the tumor site.

Loss of RB resulted in a dramatic evolution of gene expression as a result of alterations in epigenetic programming.

These data indicated that the enhanced growth characteristics observed in the RB-deficient, recurred cells were the result of a dramatic deregulation of gene expression caused by alterations in epigenetic programming.