Sentence examples for alterations in addition to from inspiring English sources

After assembly of these barcodes into genome-wide physical maps, complex genome structure is revealed, characterizing genomic alterations, in addition to providing scaffolds for genome sequence assembly, or validation.

In wt neu-expressing mice under the MMTV promoter, focal mammary tumors arise next to hyperplastic mammary tissue after a long latency period (17 48 weeks) [3], suggesting that genetic alterations in addition to that inducing HER2 overexpression are required for mammary transformation.

Identification of molecular alterations in addition to BRAF may help explain why resistance develops more quickly in some patients, and suggest rationale strategies to overcome resistance.

The1q/16q subtype with very few copy number alterations in addition to gain of 1q and loss of 16q was associated with the best patient outcome, consistent with other studies.

To prove that FADD deficiency is responsible for loss of TRAIL-induced activation of NF- κB in FADD-deficient JURKAT cells, a rescue experiment was performed, as they might have acquired further alterations in addition to loss of FADD expression.

These cells have accumulated a number of other oncogenic alterations in addition to and presumably prior to Smad4 inactivation [ 6, 7], likely explaining the TGF-β resistance of Smad4 re-expressing derivatives.

Oncogenic alteration in addition to EBV infection might synergistically contribute to increase the activation of STAT3 and NF-κB in patients with EBVDLBCL-E.

In order to determine yet unidentified disease-related genetic alteration in addition to the previously identified (WRN and LMNA), we screened differentially methylated gene promoters of the non-mutated samples for common regulatory mechanisms.

It has been demonstrated that diabetes-induced oxidative stress and lipid alteration, in addition to a marked glucose elevation, play a detrimental role in the onset of nephropathy in diabetic animals [ 22, 23].

To our knowledge, no investigators have concurrently looked for alterations in porins in addition to promoter-attenuator mutations.

Silva and Lima [ 23] verified that physical exercise practiced by elderly people provided significant alterations in BMI, in addition to improving cardiac efficiency by reducing HR at rest by up to 10 bpm after 10 weeks of activities.