However, functional and structural alterations identified in patients experiencing VM also resemble those previously described for migraine.
Being regarded as a crucial factor for the aetiology of ASD, genetic alterations identified in affected patients are remarkably heterogeneous across the whole genome [2].
The discovery of anticancer drugs is now driven by the numerous molecular alterations identified in tumor cells over the past decade.
Alterations identified in vestibular migraine resemble those previously described for migraine, but also extent to areas involved in multisensory vestibular control and central vestibular compensation possibly representing the pathoanatomic connection between migraine and the vestibular system.
We find that cell lines faithfully recapitulate oncogenic alterations identified in tumors, find that many of these associate with drug sensitivity/resistance, and highlight the importance of tissue lineage in mediating drug response.
Here, we report how cancer-driven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy number alterations, DNA methylation, and gene expression) can be mapped onto 1,001 molecularly annotated human cancer cell lines and correlated with sensitivity to 265 drugs.
Many genetic alterations identified in mouse models have a common genetic equivalent (or ortholog) in humans.
Next, we analyzed whether these phenotypic alterations identified in supporting and hair cells affected nerve fiber growth.
In addition, some alterations identified in parental cell lines were not retained in the tolerant derivatives (Table S1).
One of the DTFs, GATA3, may play a crucial role in ccRCC, as it can potentially regulate all three biologic alterations identified in ccRCC: loss of renal epithelial differentiation, adipogenic differentiation, and immune activation.
Many of the chromosomal elements such as low copy repeats (LCR), and segmental duplications (SD) which have been associated with structural alterations identified in diseases such as autism, neurofibromatosis and Sotos syndrome (OMIM) have been ruled out in the case of the DMD hotspot [15] and recently in the chr6q26 hotspot [16].
