Sentence examples for alterations highly from inspiring English sources

PMA was finally shown to cause epithelial-mesenchymal transition (EMT) in HepaRG cells and exposure to various additional EMT inducers, i.e., hepatocyte growth factor, tumor growth factor-β1 or the HNF4α inhibitor BI6015, led to transporter expression alterations highly correlated to those triggered by PMA.

This finding is particularly striking for EGFR amplification and LOH on chromosome 10, two alterations highly associated with increased malignancy (Bigner and Vogelstein, 1990; von Deimling et al, 1992; Reifenberger et al, 1996).

For example, mutations in Nrxs and NLs are found in ASD patients (Südhof, 2008) and Eph receptor alterations are highly related with AD (Chen et al., 2012).

Regarding cyanotoxins, in most cases, the liver and renal histological alterations were highly important (Fisher and Dietrich 2000; Molina et al. 2005; Lang et al. 2006Li et al. 2007a; Gutierrez-Praena et al. 2011).

Thus, mitotic alterations are highly relevant for carcinogenesis.

Previously, our laboratory demonstrated that PARP-1 inhibition affects atherosclerotic plaque dynamics and these alterations are highly desirable for the control of plaque progression and promotion of stability [15], [16].

In previous studies that have determined the entire mtDNA sequence in order to identify mutations in a small amount of cells in comparison to reference cells and which have identified a correlation between the mutation(s) and biochemical defect [14], [15], the reported mtDNA alterations are highly likely to be real rather than artifactual and the inferences are convincing.

In this study, we attempted to characterize the genetic alterations in highly malignant aggressive cells.

These alterations were highly reminiscent to the phenotype of chloracne/ metabolizing acquired dioxin-induced skin hamartomas" (MADISH) patients.

These alterations were highly reminiscent to the phenotype of metabolizing acquired dioxin-induced skin hamartomas (MADISH) patients.

Notably, the transcriptome alterations were highly related to hormone and stress responses, and many top up-regulated genes in 4× were associated with stress response.