Minisatellite alterations generated by perturbation of any of these pathways occur via homologous recombination.
These data should make anyone who routinely performs aCGH in a clinical setting sit up and reconsider how they interpret the wealth of copy number alterations that are generated from the analysis of even a single disease patient, and show that the gene-centric approach to genetic disease is a rather shortsighted one.
In strains, this metabolic alteration generated a moderate improvement in the levels of butanol from the strain; peak levels increase from ~175 to ~300 mg/L.
However, these results might be misleading because additional genetic alteration(s) or kinase activation might be generated from the long-term in vitro culture of these two breast cancer cell lines.
In the search for blood biomarkers in neurological disorders, determination of molecular signatures or pathway alterations becomes critical in the analysis of microarray data generated from the blood compartment.
NTP resulted in alteration of mitochondrial membrane potential and accumulation of intracellular ROS generated from the mitochondria in HNC cells.
Following our own system for detecting genetic alterations in formalin-fixed paraffin-embedded by FISH, we distinguished cells without any gene alterations (group 1), cells with any possible genetic alteration (group 2) and cells with cutting artefacts (group 3), including nuclear fragments generated from sectioning of the nuclei (Piqueras et al, 2009).
First, in the course of tumor progression, cancer cells with stem-like capabilities can be generated from differentiated pre-malignant cells by acquiring specific genetic alterations.
These results were correlated to differences in pore morphologies and fiber orientation distributions generated from the different processing techniques, which revealed that the alteration of the fiber density is an effective method for enhancing air filtration performance.
The named effects finally result in higher expected customer cash flows (Krafft 1999) and in an alteration of the customer lifetime value (CLV), which is the present value of all future profits generated from a customer (Gupta and Lehmann 2003).
