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A second research aim of this study was to determine the sensitivity of SSc-specific histological alterations, focusing on SSc patients without clinical skin involvement (lSSc).
Recent advances in computer-aided diagnosis now offer the opportunity for a standardized measurement of radiographically visible alterations focusing on the small joints of the hand [ 3], with a focus on the assessment of joint space widths [ 4].
The few studies published on urine cell-free DNA alterations focus on their use as markers of early bladder cancer diagnosis [ 15, 17, 18].
Historically, the investigation of genetic alterations has focused on the study of single genes.
Since 5p, 8p23, 8q24, 9q33-q34, 11q25 and 20q are regions with many alterations, we focused on these areas.
To further characterize these epigenetic alterations, we focused on individual genes that were aberrantly regulated in both the clinical NEPC cohort and in LTL331R.
The aim of this review is to provide the current state of knowledge about epigenetic alterations, focusing mainly on DNA methylation, reported in odontogenic tumors.
Because of the intense interest in identifying key somatic alterations, investigation has focused on techniques for screening or analyzing regions of interest.
As stromal cells showed the fewest gene expression alterations, we further focused on biopsy and laser microdissected epithelial samples.
To identify potentially causal mutations that induce protein coding alterations, SNP analysis focused on SNPs leading to changes in amino acid sequences.
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