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The induction of these biological events sufficiently justifies the cellular morphological alterations evidenced in the GFER-silenced glioma cells compared with control cells.
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Gross genomic alteration evidenced by aneuploidy is usually the result of chromosomal instability [ 15].
In summary, this study uncovers a high vulnerability of SGSs to ER proteostasis alterations as evidenced by the adverse secondary consequences of the alterations in translational fidelity triggered by aminoglycoside treatment.
The time- and stage-dependent accumulation of genetic alterations, as evidenced by loss of heterozygosity, suggests that a multistep process characterizes the natural history of sporadic SCC [14].
These alterations were evidenced through changes in the ADC values and were most obvious in the cortex and hippocampus.
The tumor genomic alterations were evidenced by means of the allelic imbalance at 33 microsatellites (MS) mainly localized in chromosomal regions previously described as being frequently altered in colorectal cancer [ 14, 15].
The microstructures were not greatly affected by cooling rates between 1 and 5 °C/min or by introducing 10 times as much Cs and Sr. Protracted leach tests at 90 °C showed surface alteration as evidenced by SEM and particularly transmission electron microscopy; the main alteration phase was a Zn aluminosilicate but several other alteration phases were evident.
While intrinsic force (i.e. force induced by MVC + superimposed tetanus, [2]) was not assessed in the present study, large peripheral alterations have been evidenced by the alterations of the absolute high frequency doublet, M-wave alterations (lower amplitude and longer duration) and the existence of LFF.
The alteration was evidenced here by loss of replication timing properties of three unrelated loci in blood cells of prostate cancer patients.
We note that B5 displays a certain degree of high-temperature alteration, as evidenced by the presence of vapour-deposited cristobalite within the pores (Fig. 1c; see Horwell et al. 2013 and Schipper et al. 2015).
Phenotypic alterations were not evidenced when GmWRKY56 and GmWRKY106 genes were individually silenced.
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