Sentence examples for alterations essential for from inspiring English sources

This regulon initiates metabolic alterations essential for M. tuberculosis to survive in the absence of oxygen.

The expanding application of next-generation sequencing technology to cancer has revolutionized our ability to identify genetic alterations essential for carcinogenesis and to uncover therapeutic vulnerabilities.

In an important position paper published in January 2000, Hanahan and Weinberg listed six alterations essential for malignant growth: self-sufficiency in growth signals, insensitivity to antigrowth signals, limitless replicative potential, ability to evade apoptosis, sustained angiogenesis, and ability to invade the tissues and metastasize [ 1].

Identification and characterization of genetic alterations are essential for diagnosis of multiple myeloma and may guide therapeutic decisions.

Several obvious goals for future research will be to define the function of myb proteins within the nucleus, to understand the regulation of myb expression during the cell cycle, to establish which molecular alterations are essential for converting c-myb into a transforming gene, and the determine the role of myb in human malignancies.

Precise identification of genomic alterations is essential for personalized therapy in cancer.

Therefore, better understanding of the pathogenesis and identification of the molecular alterations is essential for the development of useful indicators that aid novel effective therapies for gastric cancer [ 3- 5].

The early detection of risk factors for the occurrence of these alterations is essential for a better understanding of the problem and may lead to the development of appropriate prevention and control strategies.

Consideration of drug physicochemistry and protein binding, CRRT settings and disease-related pharmacokinetic alterations is essential for individualizing dose regimens with the purpose of attaining pharmacodynamic targets associated with success.

Understanding the mechanisms underlying type 1 diabetes-induced alterations of spermatogenesis is essential for the development of a strategy to prevent/alleviate them.

Furthermore, they can undertake post-translational modification of enzymes such as glycosylation or formation of disulfide bridges, alterations that are often essential for enzyme stability and sustained activity.