The phrase "alterations entails" is not correct in standard written English.
The correct form would be "alterations entail" since "entail" should agree in number with the plural noun "alterations."
Example: "The project requires several alterations that entail significant changes to the original design."
Alternatives: "alterations involve" or "alterations require".
Cell transformation often entails alterations in energy metabolism to accommodate adaptation in cellular functions as well as to reprogram the interactions within the cellular environment (Tennant et al., 2009).
Separation of S1 entails alteration of the anatomy at the lumbosacral junction that affects load bearing at the region.
This study was designed to investigate whether such changes have entailed alterations in duration of different developmental phases: vegetative, generative and grain filling phases and pre-anthesis generative sub-phases such as pre-fertile, pre-abortion, fertile pre-abortion, fertile and abortion sub-phases.
Such changes in nuclear organization may also entail alterations in the epigenetic make up during cell senescence or vice versa.
The negative correlation between PHAHs and allergic responses in adolescents suggested that exposure may entail alterations in the immune status.
Attempts to prevent metabolic acidosis have entailed alterations to circuit prime fluids, including partial replacement of chloride by rapidly metabolised anions such as L-lactate [ 5, 6], acetate and gluconate [ 3, 7], or else by bicarbonate [ 8].
Medium effect SNPs are also nonsynonymous substitutions, but not as disruptive as those in the previous class: they cause alterations that probably entail a lower functionality of the protein, but that can be tolerated (codon change, codon insertion, and codon deletion).
Potential pathways might entail alterations of the hormones involved in growth regulation and adipogenesis (i.e., thyroid, steroids, and growth hormone) (Cocchi et al. 2009; Diamanti-Kandarakis et al. 2009; Garten et al. 2012; Grun and Blumberg 2009) or of regulation of behavior by the central nervous system (ATSDR 2002).
S-Nitrosylation has also been implicated in neuropathogenic roles inherent in Alzheimer's and Parkinson's disease; these roles entail alterations of mitochondrial dynamics (by affecting via S-nitrosylation of the dynamin-related protein 1 (DRP1)) as well as S-nitrosylation of protein-disulfide isomerase that mediates protein misfolding.
Engineering can entail alteration of amino acid sequence, alteration of the glycocomponent of a glycosylated protein, or the covalent attachment of chemical moieties such as polyethylene glycol.
