Sentence examples for alterations drive from inspiring English sources

LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers.

Whether metabolic alterations drive tumorigenesis or are a consequence of malignant transformation is still a matter of debate.

Cancer is the product of a somatic evolutionary process, in which successive advantageous genetic and epigenetic alterations drive the progression of the disease (Greaves and Maley, 2012).

Consistent with the multistep nature of human carcinogenesis, additive host cell alterations drive progression to invasive cancer (Snijders et al, 2006).

Considering that somatic cell reprogramming does not require particular genetic alterations, but rather a reorganization of the epigenome, cancer development through the transient expression of reprogramming factors raises the possibility that epigenetic alterations drive carcinogenesis.

Although whether metabolic alterations drive tumorigenesis or are an effect of transformation is still under debate, subsequent studies showed that increased dependence on glycolysis is observed in the majority of tumors and that glycolysis provides ATP as well as the metabolic intermediates essential for cancer cell proliferation and tumor development [8], [26], [27].

The accumulation of somatic genetic alterations drives carcinogenesis.

While numerous efforts have been put forth to characterize flow regime alterations driven by climate change and human activities, few approaches have been proposed to explore changes in watershed resilience.

However, we cannot exclude that in combination with transcriptomic alterations driven by epigenetic histone modifications also acetylation of nonhistone proteins may explain the observed phenotypes.

Thus, any contribution of genetic alterations driven by this promoter to Müllerian carcinogenesis can only be mediated through a cell-nonautonomous mechanism, hence its importance in our overall strategy.

The top thirty biochemicals that drove the ability to accurately classify samples from responders versus nonresponders are shown in Figure 3. Metabolic alterations driven by metformin in the responders primarily related to elevated lipid metabolism, more efficient amino acid metabolism, increased xenobiotic presence, and altered gut microbiome-associated metabolites.