Sentence examples for alterations down from inspiring English sources

If there is a silver lining to be found in this legislation by those suffering from non-terminal but intolerable and incurable disease, it may rest in the fact that the government hasn't shut the door to legislative alterations down the road-we can only hope the Charter becomes the force by which that door is blown wide open.

This approach enables us to detect both large-scale and gene-size copy number alterations down to ~35 kb in size.

The applied variant filtering strategy narrowed the number of shared heterozygous alterations down to a single missense variant in the LZTS1 gene which was found to segregate with the disease phenotype.

One point that needs further investigation is whether this alteration (down-regulation) occurs as an early/late consequence of the disease, or may act as a susceptibility factor that influences the onset of the pathology.

Indeed, DF-1 cells retain various genetic alterations of down-regulated p53 function, an up-regulated pRB (retinoblastoma protein) and E2F1 pathway, and elongated telomere length, which are commonly found in immortalized cells [ 19].

Functional alterations include down-regulation of oestrogen and progesterone receptors as well as cell proliferation (Critchley et al., 1998b; Salmi et al., 1998).

Expression arrays showed that about 4% of the Drosophila genome altered in expression and about half of the alteration was down-regulation.

There are genetic and epigenetic alterations for the down-regulation of many genes.

Substantial transcriptome alterations (especially the down regulation of GO category transcription) observed in Atnudt7-1 plares are in agreement with reports in the animal literature (Fig. 8).

(III, B) Correct any lipid profile alterations to both slow down the progress of nephropathy and reduce the associated cardiovascular risk.

Several recent studies have begun to shed light on ehrlichial immunopathogenesis, with infection of human macrophage cell lines resulting in transcriptional alterations associated with down-regulated macrophage function [ 24], with production of dysfunctional cytotoxic TNFα by CD8 T lymphocytes [ 21], or by direct stimulation of NKT cells to produce excessive quantities of IFNγ [ 25].