The phrase "alterations directly" is correct and usable in written English.
It can be used when discussing changes or modifications that are made in a straightforward or immediate manner.
Example: "The designer made the alterations directly on the original blueprint to ensure accuracy."
Alternatives: "changes immediately" or "modifications straightaway".
You can read more about these alterations directly from Apple's work, entitled Learning from Simulated and Unsupervised Images through Adversarial Training. .
Because these alterations directly affect the fate of renal damage, definition of these alterations is of utmost importance from the clinical point of view.
Dermal ALMS fibroblasts display a constitutive activation of an α-SMA-myofibroblast like phenotype, indicating autonomous, signal-independent alterations, directly due to mutations in ALMS1 gene.
In addition, it will be of interest to test whether genetic alterations directly affecting the genes for theses enzymes can be evidenced in cancer.
Both of the negative controls (monkeys Q12 and I2) developed non-significant biochemical alterations directly following the liver puncture procedures.
Some of these alterations directly affected gene expression, whereas others were significantly associated with the clinical outcome of patients.
This allows one to suggest that alterations made directly in membrane and microdomains architecture can be treated as one of the areas of Minerval activity.
Since most patients survive the first days of sepsis, it has been postulated that acquired immune alterations may directly participate in a worse outcome through the inability to clear the initial infectious focus and/or decreased resistance to ICU-acquired infections.
Despite recent studies demonstrating miRNA expression profiles correlating with tumor histology, as well as smoking status and prognosis of patients with primary lung cancers, [6], [20] [22], limited information is available regarding miRNA alterations that directly contribute to initiation and early progression of these malignancies.
These alterations contribute directly or indirectly to increased ratio of cell birth to cell death [ 3].
As opposed to mRNAs, miRNAs are active moieties by themselves and should thus reflect physiological alterations more directly (Gilad et al, 2008).
