Sentence examples for alterations determined from inspiring English sources

We hypothesized that molecular alterations determined through studies of in vitro senescence would be evident in the context of advanced organismal age, supporting a role for this cellular program in prostatic diseases.

These two plants also were effective in inducing cellular alterations, determined by characteristic ultrastructural changes which could reflect cytotoxic activity.

A binary logistic model was used to consider subject characteristics, including age, education, HIV, race, and gender, as predictors of brain alterations, determined by k-means classification.

The aim of this study was to analyse genetic alterations determined by array CGH in MYCN-non-amplified localised unresectable/disseminated NB of infants included in the prospective European INES99.1, INES99.2 and INES99.3 protocols (De Bernardi et al, 2009; Rubie et al, 2011) and to study the impact of the genomic profile on clinical characteristics and outcome in this population.

In particular, targeted histone alterations determine the epigenetic state of the genome.

The net effect of growth promoting and inhibiting alterations determine whether RBM47 loss is beneficial for a particular cancer clone.

Although crystallography studies using 'short' and 'long' ALR have demonstrated that the proteins can form homo-dimers [ 32- 35], whether and how these modifications as well as post-translational alterations determine the functions of ALR in physiology and pathology remain to be determined.

As yet unexplored mechanisms such as copy number alterations determine the variance in VAFs and so we do not yet know whether the sensitivity of our study limited the detected number of mixed-lineage clones, or whether our results are an accurate estimate of the typical number of mixed-lineage clones in pathologically well-defined samples.

This study focused on in-patient female breast cancer tissue samples with final histopathologic diagnosis of invasive ductal carcinoma of no special type, with archival paraffin blocks, and with prior Her-2/ neu alteration determined by IHC from 1 January 2000 to 31 December 2001 in our laboratory.

Importantly, this alteration determines a markedly shorter overall and PFS, especially in the subgroup of patients younger than 70 years.

Our hypothesis is that the dominant alteration determines whether glaucoma manifests as normal-tension glaucoma or as high-tension glaucoma.