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An understanding of these alterations could provide novel biomarkers of disease as well as new treatment targets for anticancer therapies [ 4].
To elucidate if the observed alterations could provide a signature for each type of tissue, we applied unsupervised hierarchical clustering analysis (see Supplementary Methods section in Additional file 1 for more details) to the data obtained for 98 patients and 50 healthy donors.
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Computational analysis suggested structural alterations that could provide additional interactions with RT and thus improve inhibitory potency.
Chromosomal aberrations, together with more accurate information of gene expression alterations caused by asbestos, could provide valuable clues in the search for novel therapeutic targets.
In cases where no remarkable histologic abnormalities are found, investigation into molecular alterations causing placental dysfunction could provide insight into the pathogenesis of prematurity.
Therefore, an integrative approach to analyze all types of genetic alterations in a pathway context could provide greater insight into the genetic mechanisms of cancer development.
These data and immediate release of ALR in circulation following partial hepatectomy [ 21] suggest that alterations in serum ALR levels could provide an indication of hepatocyte stress or injury.
However, it is possible that changes in decomposition and the alteration of some metal records could provide climatic information.
Relationship between the filter operating condition and the bacterial community alteration was partly revealed, which could provide the basic knowledge for the filter design and its practical use.
Even though we could not detect any major modifications in myelin structure in Ins2Akita/+ PNS (Fig. 3A C), subtle molecular alteration in myelin gene expression could provide an early marker of later stage irreversible pathological changes.
We believe transcriptomic alteration characterized through this comparison could provide insights into mechanisms of early embryonic development and may help identify biomarkers for growth defect in IVF and for infertility in cattle.
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