As demonstrated in previous studies, although gene expression of cancer cells reflects genetic and epigenetic alterations, a considerable fraction of this gene expression can nevertheless be characteristic of the non-transformed cell-of-origin.
Interestingly, in contrast with R6/2 and some of the knock-in mice where there are considerable alterations in receptor expression, alterations in YAC128 mice appear limited to glutamate receptors, as DA, GABA (γ-aminobutyric acid) and adenosine receptor binding remained unchanged (Benn et al., 2007).
With respect to the steroidal hormone status of the animals, in males the majority of the diets induced considerable alterations in the circulating T/E ratios, while only the 40% CR diet induced a significant alteration in the T/E ratio in the females.
These results may indicate that a slight alteration in ELA1 mRNA levels reflects a considerable alteration in phenotype, as observed in Figure S3E.
The Borana rangelands have undergone considerable alterations between 1987 and 2003.
Strong increase of hole mobility and decrease of hole concentration have been observed in CrSi2 epitaxial films on Si(111) [3] that corresponds to considerable alterations in their band structure.
The heterogeneity of alveolar microstructure that is accounted for in image-based models resulted in considerable alterations to the shape of the 129Xe diffusive uptake curve when compared to 1D models.
However, we did not find any considerable alterations in HAT activity with SFN treatment in these breast cells (Fig 5C).
Given the functions of miRNAs in post-transcriptional gene silencing, loss of Dicer and all microRNAs would be expected to result in considerable alterations in mRNA levels and associated phenotypic changes.
Considerable alterations in the DNA binding activity of SRF upon serum induction are either not observed or are associated with additional events such as phosphorylation, depending on the cell type, the stimulus and the target gene [22], [23], [24], [25].
