Sentence examples for alterations conferring from inspiring English sources

At variance with the great majority of protein kinases that become active only in response to specific stimuli and whose implication in tumors is caused by genetic alterations conferring to them unscheduled activity, the highly pleiotropic Ser/Thr-specific protein kinase CK2 is constitutively active even under normal conditions and no gain-of-function CK2 mutants are known.

The strong rationale in combining anti-ERBB2 agents with PI3K/AKT inhibitors, together with the identification of genomic alterations conferring sensitivity to targeted inhibition, are guiding the design of clinical studies aimed at preventing the emergence of drug resistance and achieving more durable response.

11 Despite the cell of origin, alterations conferring stemness to cells may increase their fitness and favor tumor development.

De novo drug resistance can be determined by assessing the genetic profiles of tumors for 1) oncogenic addictions to proteins or pathways and 2) other possible genetic alterations conferring resistance [ 2].

Most similarities were found among the different stages of breast tumour progression, and it was suggested that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stadium of breast cancer (Ma et al, 2003).

While transcriptomic differences are apparent between normal and cancerous tissues, the expression of TAs remains relatively constant through different cancer stages, suggesting that most defining genetic alterations conferring a cancerous potential occur at the early stages of tumorigenesis [ 37].

Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation.

Notably, we found that the same alterations confer sensitivity to acetic acid-induced PCD in yeast.

These alterations confer resistance to cisplatin through the activation of PI3K.

10 Similarly, CDKN1A/p16 alterations confer a significantly worse survival among patients aged over 70 years compared with patients aged under 70 years.

Furthermore, recent evidence has suggested that the ability of tumor cells to acquire an aggressive phenotype may result from accumulation of genetic alterations conferred by extended survival [ 7, 8].