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Exact(16)
Whether the observed microvascular dysfunction could also be associated with cellular or mitochondrial alterations cannot be ruled out from this study [44].
However, more discrete alterations cannot be discarded and additional experiments using germ-free animals and/or molecular methods for bacterial detection are required to further explore the relationship between Card15/Nod2 and the normal gut flora.
Importantly, these alterations cannot be considered individually as usually a number of properties are influenced simultaneously.
Such alterations cannot be identified until the function and regulation of BRCA1 are better understood.
Since our methods are based on affinity purification, methylation changes and karyotypic alterations cannot be distinguished.
These receptor alterations cannot be monitored by classical light microscopy with a diffraction limit of 250 nm.
Similar(44)
Given the fact that a minimal value was used, a threshold of FO alteration cannot be determined.
The classical criteria of assigning a pathogenic condition to any de novo alteration cannot be always applied, as exceptions in both senses can occur: benign copy number variants (CNVs) can arise de novo (unpublished results) while some pathogenic alterations are associated to such a broad phenotypic spectrum that they may have been inherited from apparently healthy parents [ 1].
These could be disparate events that are independent of infection, although it is also possible that epigenetic events are influenced by the parasite to generate infected cell-associated alterations that cannot be altered by drug treatment over 48 h.
There are 22 genes with stage-dependent expression alterations that cannot be explained by CNV, altered methylation, or dysregulated transcription, which suggests that other regulation programs responsible for expression alterations in the late stage are not included in the model.
Hence the alterations seen cannot be exclusively due to perturbed complex formation of GNB1 and GNG1 as supported by PhLP1.
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