Sentence examples for alterations can play from inspiring English sources
GH secreting adenomas of anterior pituitary gland which may arise from clonal expansion of somatotroph cells almost always underlie acromegaly disease and this monoclonal origin suggests that intrinsic genetic alterations can play an important role for possible tumorigenic initiating mechanisms [ 22].
In this study we investigate if successful anti-TNF-α treatment alters the levels of early mitochondrial genome alterations, which can play a crucial role in governing clinical response or resistance.
As many of these processes are often modified in cancer it is clear how alteration of IAPs can play a role in tumorigenesis not only as a consequence of altered apoptosis.
Deletion of FAK in mice B-cells results in impaired glucose-dependent insulin secretion, glucose intolerance and eventually in loss of β-cells, strongly suggesting that alteration of these pathways can play a role in diabetes pathogenesis.
Alterations in HPA axis activity can play different roles at different stages of alcohol dependence.
Since WaaR is the target of RybB sRNA and GlmY/Glm Zare required for synthesis of UDP-GlcNAc, this implies that LPS alterations by such sRNA-mediated interaction can play important role in bacterial adhesion and phagocytosis.
Alterations of these negative effectors of Ras also can play a role in tumorigenesis.
Furthermore, alterations in the functional capacity of these fibroblasts can play a role in the pathogenesis of pulmonary emphysema, which results in a breakdown of the tissue.
Overall, these data suggest that alterations in TNF-mediated NF-κB activation pathways can play a role in the development and progression of HPV-associated epithelial and mucosal lesions.
Recoding is the reprogramming of mRNA translation by localized alterations in the standard translational rules and recoding products can play critical cellular roles [ 34].
These findings also show that the salivary glands can play a key role in mediating tumor-induced alterations in saliva transcriptome biomarker profile.
