This modification can modulate protein function [24].
This idea is consistent with our findings that there were significant alterations in chemokines and their receptors expressed in the cKO oviduct and that there were alterations in PGs, which can modulate chemokine secretion (Kalinski, 2012).
Most importantly, disruption of mitochondrial fission can inhibit Reaper and Hid-induced cell death, suggesting that alterations in mitochondrial dynamics can modulate cell death in fly cells.
Alterations in membrane sphingolipids can modulate the level and activity of nutrient transporters [ 3, 113, 129, 130] and therefore impair nutrient uptake and indirectly induce autophagy.
In order to investigate whether alterations in intracellular GSH can modulate the toxicity of SiO2 nanoparticles, MCF-7 WT cells were treated with 50, 100, and 200 μM buthionine-[S,R]-sulfoximine (BSO, Sigma-Aldrich) for 24 h, and the reduction in intracellular GSH was confirmed using the ThioGlo-1 assay.
In summary, we show that dietary amino acid manipulation, in which protein is partially replaced by free ketogenic essential amino acids, can modulate metabolic alterations and prevent hepatic steatosis in mice models of diet-induced obesity.
The data presented suggests that alterations in snoRNA expression profile can modulate the sensitivity of human cells to drugs.
HDAC inhibitors can modulate cell responses through alterations in gene expression, induction of cell cycle arrest, inhibition of growth, and induction of apoptosis.
With a very simple biochemical model, it is demonstrated that a proteolytic enzyme can modulate the Overhauser effect through the alteration of the motional correlation time of a nitroxide labelled substrate.
12 Thus, SIRT1 can modulate various cellular signaling pathways through alteration of the acetylation status of target proteins.
