The phrase "alterations by using" is correct and usable in written English.
It can be used when discussing changes or modifications made through a specific method or tool.
Example: "The artist made several alterations by using different techniques to enhance the painting."
Alternatives: "changes through the use of" or "modifications by employing".
After detecting specific white-matter alterations by using the TBSS method, we performed a more detailed investigation of the alteration by using tractography.
They investigated the DNA copy number alterations by using representational oligonucleotide microarray analysis (ROMA) [ 18], which allowed them to detect many small and larger deletions.
We have investigated the relative strengths of using family history and tumour morphology, as well as both criteria together, to select the women with early onset breast cancer most likely to carry BRCA1 mutations (including large genomic alterations) by using the BCFR [ 18].
Instead, we considered it more important to increase our chances of finding sequence alterations by using cDNA rather than genomic DNA because of the lower cost, time, and labor involved in sequencing cDNA, as well as the increased relevance of only studying genes that are expressed in the colon.
In the past decade, there have been considerable improvements in the way that human breast tumours are identified and characterized, uncovering biomolecular alterations by using different technologies (like DNA assessment and mutation screening, gene-expression and microRNA, proteomic-metabolomic-degradomic profiling, etc).
Moreover, we attempted to characterize the putative effects of the amino acid substitutions on protein structure or function, as well as on mRNA stability by using bioinformatic analyses; we also tried to define the effect of mutations near splice site on mRNA processing alteration by using the same approaches.
Since we did not have the availability of the cDNA of patients with mutations close to splicing sites, we attempted to define the effect of mutations near splice site on mRNA processing alteration by using the web server tool, Splice Site Prediction by Neural Network.
To verify the clinical relevance of YAP up-regulation in the cervical cancer, we performed a cross-cancer YAP gene alteration analysis by using the multidimensional cancer genomic datasets and online analysis tools.
The objective of this study was to determine the regional distribution of NAA and mI alterations in AD by using MR spectroscopic imaging.
Ultrastructural alterations were analyzed by using TEM thin sectioning technique as reported earlier with minor modifications.
Presently a comprehensive and detailed genomic profiling of DNA alterations is possible by using the single nucleotide polymorphism (SNP) array technology.
