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Once a tissue or system is fully developed, while still somewhat plastic, it is less sensitive to alterations by environmental stimuli.
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There are many more mechanisms of gene regulation that are potentially susceptible to alteration by environmental influences.
Evidence from animal studies indicates that many lung alterations induced by environmental chemicals require functional and/or highly specific studies targeted at identifying alterations of structure or function.
Plastids reside both at the receiving and acting end in various cellular processes and alterations caused by environmental cues [65].
Primary tumors can be either caused by genetic alterations or by environmental factors.
Given that the correction of genetic mutations is not a feasible cancer therapy, epigenetic alterations caused by environmental factors may make better targets.
However, the alteration introduced by environmental factors might prove to be beneficial for a cell or an organism in a given environment.
Epigenetic modifications occurring during embryonic development are well recognised as being susceptible to alterations by exposure to environmental factors.
Epigenetic alterations may be induced by environmental exposure, particularly in early development [ 16].
An additional epigenetic mitochondrial interaction could be the alteration of mtDNA methylation by environmental stressors, although it is currently unclear whether mtDNA transcription is linked to altered mtDNA methylation in the same manner as is nuclear DNA (nDNA) methylation.
Therefore, epigenetics can directly influence genetic mutations and the origin of genotypic variation is influenced by environmental epigenetic alterations (table 1).
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