The phrase "alterations at specific" is not complete and lacks clarity in written English.
It could be used in contexts discussing changes or modifications that occur at particular points or locations, but it needs additional information to be fully understandable.
Example: "The report outlines the alterations at specific intervals during the experiment."
Alternatives: "changes at particular" or "modifications at designated".
Each of the currently known IDs was initially reported to be associated with molecular alterations at specific chromosomal loci.
We have applied high-density SNP-oligoarray to detect copy number alterations at specific chromosomal regions in chromophobe RCCs and ROs, which may mark the loci of genes involved in tumor development.
CEL files with raw chip intensity data were analyzed for copy number alterations at specific loci previously reported to be associated with ependymoma using segmentation algorithm in Partek Genomics Suite (v6.6).
Non-double-stranded structural elements within genomic DNA provide enticing targets for recognition and alteration at specific regions of the genome thus controlling transcription at single gene resolution.
These data support the notion that persistent inflammatory conditions offer powerful chemical, biological and environmental hazards in causing additional genetic alterations at site-specific tissues.
We expected that neonatal habenula lesion (NHL) caused behavioral alterations that were different from those induced by adult habenula lesion, and neurodevelopmentally-specific alterations (e.g. alterations presenting only at specific ages) in the brain areas such as the PFC and NAcc where monoamine neurons projects.
Extensive, but small, alterations in methylation at specific sites were observed in weight loss intervention studies, and several associations between methylation marks at birth and later life obesity were found.
This inhibition of the ubiquitin proteasome pathway likely alters protein turnover of transcription factors and histone-modifying enzymes and is associated with epigenetic alteration at a specific lysine residue (K9) of histone H3 (i.e. increased H3K9-ac and reduced H3K9-me2) as well as DNA hypomethylation (Oliva et al. 2009 ).
Loss of function of proteins encoded by such genes is expected to result in alterations of epigenetic marks at specific genomic loci.
Quantification of mRNA content in tissue may however be a valid means to measure increased or decreased alterations in protein production at specific conditions.
Taken together, these observations suggest that deregulation of expression could be associated with genetic alterations that may occur at specific chromosomal loci in the development of tamoxifen resistance.
