Sentence examples for alterations at multiple from inspiring English sources
One-third of the tumours had alterations at multiple loci.
Hence, the evolution of an important trait like brain function may require genetic alterations at multiple regulatory levels.
We investigated 35 trebouxiophycean taxa and three pedinophyceans and found that the chloroplast genome experienced important alterations at multiple levels during the evolution of the Trebouxiophyceae and Pedinophyceae.
These differences involved frequent alterations at multiple chromosome locations in luminal BRCA2 tumors that were infrequently or inversely altered in basal/TNP BRCA2 tumors.
With regard to the number of altered loci, 18 tumours (51%) showed alteration at only one locus and 11 (31%) showed alterations at multiple loci (Table 3).
Some patients show alterations at multiple ICRs within the cluster, but the most consistent aberration is hypomethylation of the A/B differentially methylated region directly upstream of the major coding isoform of GNAS.
Continuous attempts to fully describe the functional alterations at the multiple levels of gene regulation in cancer will be instrumental to the effective interpretation of cancer molecular data and to their translation into the clinic.
Clonal spread of p53 mutation and microsatellite alterations (LO Hand MA) at multiple foci in normal appearing bronchial epithelium has been reported earlier [10] [12].
The present study extends that work by demonstrating that simulating oxidative stress in isolated cells by treatment with hydrogen peroxide causes an enhanced and prolonged increase in the response of TPβ receptor to ligand binding, and that this is most likely a result of an increase in cell surface TPβ receptor population mediated via cellular alterations of the TPβ receptor at multiple levels.
Soubry et al. demonstrated the presence of alterations in the methylation status at multiple imprint regulatory regions in children with obese parents, suggesting a preconceptional influence of parental lifestyle and nutrition on the programming of imprint marks during gametogenesis [ 166].
Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [ 18].
