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However, the TEM analysis reveals extensive solid phase alterations as discussed in the next section.
However, underlying genomic alterations, as discussed in the following sections, may significantly enhance our ability to predict neoplastic behavior.
These compounds can confer better protection against the damage caused by free radical formation in comparison to conditions in which no antioxidants are present, thus preventing mutations resulting in genetic and chromosomal alterations, as discussed by Prasad et al. [ 31] and Getoff [ 32].
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The prevalence of normal DNA and the large dilution of free tumor DNA by normal DNA may hamper detection of genetic alterations in blood as discussed by several laboratories for other tumor entities [ 29- 32].
As discussed previously, alterations in β-tubulin expression (including the βIII isotype) are associated with clinical resistance to taxanes.
Based upon the noted alterations in phosphoprotein activation levels, as discussed above, we examined the TargetScan miRNA prediction database [ 30] for potential kinases that might be direct targets of miR-34a that could account for these alterations.
As discussed, the alterations in membrane permeability occurring during CA storage facilitates the release of both enzyme and substrate in the cytosol leading to the formation of brown pigments.
As discussed earlier, many alterations in gene expression suggest an alteration in calcium homeostasis in NPC cells (Table 3).
All the motif sequences and the alterations done to the consensus motif sequences (as discussed in the section on motif discovery) are listed in Table 6.
Neurodevelopmental alterations, as well as genetic and environmental influences, have been discussed as possible pathophysiological factors.
However, for cancer development, most of the growth alteration events are happening in the nucleus and involve altered signalling pathways regulated by protein kinases as discussed earlier.
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