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If you have conjured screenplays, as he has, from Thomas Hardy, Henry James, Elmore Leonard, and Patricia Highsmith, then le Carré is no cause for alarm, and some of Amini's alterations are well wrought.
Thyroid and renal alterations are well known lithium side-effects, while effects on parathyroids are less studied.
Complex patterns of such alterations are well documented for example for the tumour suppressor protein p53 [ 35].
Although specific tumor genetic alterations are well described and annotated [ 10], comprehensive studies are required to obtain more information about the transcriptional programs involved in tumor development.
Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact.
Mitochondrial alterations are well documented and have been described in neurodegenerative disease models including 3-nitropropionic acid for Huntington disease, β-amyloid peptide for Alzheimer's disease, and 6-hydroxydopamine for PD.
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Epigenetic alterations are well-known causes for the onset of cancer.
All of these neuroendocrine and behavioral alterations are well-known risk factors for aging and frequent features of age-associated brain pathologies such as major depression and dementia (for review [ 13, 14]).
While adverse reactions to trabectedin treatment such as neutropenia and liver function test alterations are well-known, more education and data are needed on some of the rare side effects mediated by this drug, such as the potential induction of rhabdomyolysis.
My current rule of thumb, when confronted with an enhanced face, is that if I find myself vaguely wondering whether there was work, the alteration was well done.
Its applicability is examined by real pile driving data, and it becomes clear, that the effect of the magnitude of bearing capacity, and also the accuracy of the estimation to the design alteration, is well presented in the chart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com