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These single amino acid alterations are potentially powerful biological tools for understanding the mechanisms driving tumorigenesis in LS patients.
Epigenetic alterations are potentially reversible in neoplasia, and they present new opportunities for the clinical management of cancer, which are different from mutation [ 2].
Unlike genetic mutations, epigenetic alterations are potentially reversible and a range of pharmacological reagents that reverse epigenetic modifications have been characterised in recent years (see Fig. 1).
Furthermore, epigenetic therapies for patients with chronic liver diseases may be helpful to reduce the risk of HCC development because epigenetic alterations are potentially reversible, and thus provide promising molecular targets for therapeutic intervention.
Therefore, in addition to the antiviral and anti-inflammatory therapies, epigenetic therapies for patients with chronic liver diseases may be helpful to reduce the risk of HCC development because epigenetic alterations are potentially reversible, and thus provide promising molecular targets for therapeutic intervention, especially for the subset of HCC that develops through the epigenetic pathway.
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The effects of IL-1 on vascular endothelium result in a complex set of alterations which are potentially disruptive of vessel wall and underlying tissue integrity.
Structure-selective endonucleases pose an inherent threat to genome integrity because broken DNA ends can facilitate chromosome rearrangements and genome alterations that are potentially tumorigenic.
Unlike genetic alterations, epigenetic changes are potentially reversible.
These alterations in blood glucose are potentially detrimental, although the precise relationship with outcome in patients with bacteremia has not been yet determined.
Additionally, while genetic alterations, such as mutations, are usually irreversible, epigenetic alterations, such as DNA methylation, are potentially reversible and, thus, can provide possible molecular targets for successful cancer therapy.
Cicatricial conjunctivitis is chronic conjunctivitis with conjunctival fibrosis and may lead to alterations of conjunctival architecture, which are potentially sight-threatening.
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