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These specific skin alterations are considered to be mainly the consequence of the inflammatory process and not a primary event in the pathophysiology [1], [2], [3].
Such alterations are considered benign and reverse after a period of detraining.
These multiple genetic alterations are considered to be a direct reflection of the multiple steps involved in carcinogenesis.
These alterations are considered to constitute a fundamental feature of carcinogenesis, facilitating tumor cell growth and spread [ 2, 3].
Epigenetic alterations are considered to be very influential in both the normal and disease states of an organism.
p53 alterations are considered to be predictive of poor prognosis in hepatocellular carcinoma (HCC) and may induce a humoral response.
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The accumulation of somatic ADN alterations is considered as the main contributing factor in carcinogenesis.
At least 2-fold mRNA level alterations were considered significant.
Areas of GM alterations were considered tendencies if not significant.
Thus, any SLE LDG sample that had 18 or more copy number alterations was considered ∆CNVhi.
In these and other examples of previous validation and use of copy number alterations as predictors of outcome and response to therapeutic agents, only individual alterations were considered.
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