Sentence examples for alterations are conserved from inspiring English sources

Furthermore, detected patterns of genomic alterations are conserved across independent oestrogen receptor positive breast cancer datasets.

The fact that genomic alterations are conserved for several years, without any major changes, as demonstrated by sequential CGH analysis after multiple passages in vivo, suggests that genomic profiles remain relatively stable over time despite new selection pressures and loss of human stroma.

Most of the alterations were conserved in the xenografts, such as the 1q gain, Xp22 amplification, 2q loss, and alterations in 14p, 15q, and 17.

Finally, the frequent finding of this gain in more than 60% (5 of 8) of metastatic samples, with a mean of 69.4% of nuclei containing the alteration (ranging from 47.5% to 98.5%), indicates that this alteration is conserved during all steps of tumor progression.

Because these integration sites were identified in tumors representing different developmental stages, this area corresponded to a common integration region whose alteration is conserved during tumor progression, therefore suggesting that the gene(s) encoded by this portion of genome might be critical for nephroblastoma development and (or) tumor progression.

No systematic multi-cohort analysis has yet evaluated transcriptional alterations that are conserved across neurodegenerative diseases.

Patched is a twelve-transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters; we demonstrate that the function of Ptc is impaired by alterations of residues that are conserved in and required for function of these bacterial transporters.

These results suggest that genomic alterations present in human MFH are conserved in the LSL-KrasG12D; p53Flox/Flox mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.

Despite these alterations within the catalytic loop, all other catalytic residues (Arg109, Asp168, Arg171, and His195) are conserved.

The main residues are conserved.

Both are conserved in other gamma-herpesviruses.