Sentence examples for alterations and increased from inspiring English sources

Osteoporosis is characterised by reduced mineral density and bone mass, microarchitecture alterations and increased skeletal fragility.

Numerous experimental studies demonstrated the deleterious effects of nitrogen reactive species accumulation in ischemic-reperfusion cerebral injury through depletion of energy, lipid peroxidation, protein nitrosylation, DNA alterations and increased permeability of the blood brain-barrier [19] [21].

Data in rats (24) demonstrate that preconception obesity brought about by overfeeding leads to obesity, metabolic alterations, and increased adipose tissue cellularity in the offspring.

Investigators in several clinical trials have reported that HES is associated with coagulation alterations and increased blood transfusion requirements [ 20, 21, 34].

When comparing gastric carcinoma harbouring EGFR alterations with carcinomas with normal EGFR status or copy number, we observed a significant association between EGFR structural alterations and increased tumour size.

It is known that both hypoxia and consecutive hypoxia/reoxygenation can exert a variety of effects on tumor cell biology, including activation of pro-survival signal transduction pathways, aberrant genetic and epigenetic alterations, and increased tumor angiogenesis.

Out of the drugs used, diacerein and risedronate (alone or combined with glucosamine) were the compounds with a better profile of effectiveness in ameliorating these early changes, showing a better anti-inflamatory effect (in cartilage and synovial membrane), improving the cartilage surface alterations and increasing bone density.

Another concern over orthodontic bonding and debonding procedures is related to their impacts on tooth color alteration and increased susceptibility to exogenous pigmentations and thus esthetic impairment of the enamel surface [26, 32, 33].

This correlation suggests the hypothesis that oncogenes and tumour suppressors regulate VEGF, and a significant correlation between p53 alteration and increased VEGF expression in human lung cancer was reported recently.

The findings of the reported study presented that suilysin-positive strain could show toxin to produce functional alteration and increase the permeability of BBB; and Suilysin-negative strain might stimulate the production of proinflammatory cytokines resulting in alteration of BBB permeability [ 76, 77].

By generating genetic diversity, CIN may provide cells with an increased probability of acquiring tumor-promoting alterations and an increased adaptive potential when challenged by treatment.