These AGEs crosslink proteins such as collagen and extracellular matrix proteins, leading to basement membrane alteration and, hence, endothelial dysfunction.
Are these alterations adaptive (and hence protective), or do they participate in multiple organ failure?
We hypothesized that alterations in mRNA abundances (and hence alterations in functional profiles) are regulated, in part, by specific transcription factors.
The effect of several chemotherapeutic drugs may be mediated through DNA damage and induction of apoptosis (Gewirtz, 2000), and therefore alterations to TP53 and hence p53 protein function could result in relative resistance to these agents.
A too large feeding velocity will result in alteration of TIF, and hence deteriorate efficiency of figure correction as well as MSF errors.
In an ENU-induced mutant mouse exhibiting deafness and vestibular dysfunction, a mutation in the miR-96 seed region was found to be responsible for hearing loss, presumably due to the alteration in expression and hence function of both direct and indirect gene targets [ 9].
Minor variations in calliper placement and hence alterations of mere milliseconds in time interval measurements result in significantly different Mod-MPIs [ 47].
Cases identified within a short period after the start of the study may have suffered from some symptoms, leading to dietary changes and hence alterations in the blood carotenoid levels.
Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis).
The combination of the assessment of disease-specific cellular biomarkers directly in the joint and noninvasive high-resolution in vivo imaging techniques, such as immunoscintigraphy or immuno-positron-emission tomography (PET), are suitable approaches to determine alterations in the joints and hence offer valuable tools for sensitive and specific diagnosis in RA [ 4- 7].
