Sentence examples for alterations and further from inspiring English sources

A network that simultaneously transmits information at a large rate, is robust under couplings alterations, and further, it possesses a large number of independent channels of communication, pathways along which information travels.

These data confirm the complexity of the cancer genome alterations and further emphasize the need for a System Biology approach to its pathogenesis and therapy.

The majority (66.3%) of the genes did not show significant alterations and further 29.8% showed no transcripts matching the filter criteria (Hillmann et al. 2009).

Systematic analysis of genetic/genomic alterations and further functional studies have led to several important findings, including novel rearrangement hotspots, osteosarcoma-specific LRP1- SNRNP25 and KCNMB4- CCND3 fusion genes, VEGF and Wnt signaling pathway alterations, deletion of the WWOX gene, and amplification of the APEX1 and RUNX2 genes.

Reduction in their expression causes mitochondrial apoptotic alteration and further results in MMP loss [ 35].

It should be emphasized that these experiments only provide a correlation between MYCN expression change and miRNA expressional alterations, and that further experiments involving chromatin immunoprecipitation are required to distinguish between the direct and indirect effects of this transcription factor.

We, therefore, propose that the two complementary strategies are necessary to better reveal subtle molecular alterations and, thus, further our understanding of the progression of IVDD.

As EGFR mutations are well known to constitutively activate ERK causing cancer, we decided to generate a new model of the EGF activated ERK pathway which would correctly predict the effects of various cancerous alterations and enable further investigations.

The present study confirms that these alterations are sustained and further identifies the decreased synaptic density as well as alterations to the general morphology of the molecular layer of the cerebellar cortex that are the result of the binge ethanol exposure.

Our study is the first to comprehensively set an upper bound on the frequency of other alterations in hemangioblastoma formation, and further confirm that VHL alterations can be detected in the vast majority of hemangioblastomas, establishing VHL inactivation as the central event in formation of this tumor.

An interesting exception to this was in the 25 ptumoursurs, in which p16 alteration was prognostic, and further improved by combined analysis with p53.