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Single base modifications can result in folding alterations and functional loss.
Thus, cytogenetic microarray analysis alone may not be sufficient to establish the relationship between genomic alterations and functional consequences.
Collectively, the above-mentioned studies suggest that the systemic BM compartment may be involved in the pathogenesis of RA, though currently available data on its morphological alterations and functional properties have yet to be integrated into a coherent model of disease.
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In this study, we used human epithelial cells, cultivated without glucose excess, to study alteration and functional role of glucose metabolism during OIS.
Although the authors acknowledge the risk of significant bias inherent in their retrospective data, the results are remarkably consistent with the high rate of chronic pain, sensory alteration, and functional limitation found in our prospective study.
The study produced a discovery-driven catalogue of protein-level alterations, and a functional characterization of the tumor biology of CRC.
Diseases are often caused by congenital disorder or expression of abnormal genes, which induces multi-factor-driven alterations and disrupts functional modules [ 1].
The aim of this study was to investigate, for the first time, whether PWS is associated with oxidative stress and alterations of functional and physicochemical properties (order, polarity) of high-density lipoproteins (HDLs).
In summary, significant alterations with anatomic and functional imaging of the primary tumour were observed early (by fraction 11) in treatment.
Here we report alterations in structural and functional brain symmetry of the sensorimotor network in a large sample of individuals born without a hand compared to controls.
On the other hand, the partial replacement of conventional treatment with robotic therapy is not going to lead to alterations in motor and functional recovery [ 9, 12].
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