The phrase "alterations and cell" is not correct and does not convey a clear meaning in written English.
It may be used in a context discussing changes or modifications related to a cell, such as in biology or data management, but it lacks clarity without additional context.
Example: "The alterations and cell modifications were crucial for the experiment's success."
Alternatives: "changes and cell" or "modifications and cell".
Loss-of-function WRN leads to genomic instability, heterochromatin alterations, and cell growth defects, which contribute to WS pathogenesis (Li et al., 2016; Murfuni et al., 2012; Ren et al., 2017a; Ren et al., 2011; Seki et al., 2008; Shamanna et al., 2017; Zhang et al., 2015).
Both normal and tumor tissues are heterogeneous in terms of molecular alterations and cell populations.
Increased DAPK1 expression leads to death-associated cellular alterations and cell morphology changes (Cohen et al., 1997).
Anthracyclines lead to structural cardiomyocyte alterations and cell death, which is probably mediated by reactive oxygen species (ROS) generated in iron-dependent chemical reactions.
The cause of acute tubular necrosis is thought to be multifactorial; it includes direct nephrotoxicity of the venom, hypotension, pigment-induced nephropathy secondary to hemoglobinuria and myoglobinuria, disseminated intravascular coagulation, hemodynamic alterations and cell injury induced by the release of proinflammatory cytokines and complement.
Prolonged aeration of lactococcal cultures can cause DNA alteration and cell death.
The mechanism by which IGL-1 prevents microcirculatory alteration and cell swelling, and maintains cell viability remains to be determined.
Similarly, in cultured PECs, Notch inhibition suppressed its migration and mesenchymal phenotypic transition which suggests that Notch-mediated mesenchymal phenotypic alteration and cell migration may compensate for the loss of podocytes.
As metabolic alteration and cell growth control are intertwined, p53 or STAT3 control of FGF21 expression could be cooperatively engaged with PPARs or other NRs that are master response and regulatory factors for metabolic abnormalities.
This seems also confirmed by the lack of correlation that we observed between B cell alterations and B cell HHV-8 viral load.
Damaged tubular cells undergo reactivation of developmental and epithelial-mesenchymal transition signaling, metabolic alteration, and cell-cycle arrest, thereby driving inflammation and fibrogenesis.
