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Genetic alterations affecting PARD6B and PARD6G in human cancer.
In two independent data sets, copy-number alterations affecting either <25% or >75% of a tumor's genome predicted reduced risk (HR = 0.15, 95% CI: 0.08-0.29).
Further evidence for different biological quality between PARD6B and PARD6G gene in tumorigenesis was obtained from analysis of gain- and loss-of-function-type alterations affecting these genes in cancer.
Despite a lack of previously reported NOTCH1 mutations, integrated analysis showed enrichments of alterations affecting Notch signaling in OTSCC.
Sepsis-induced immunosuppression is characterized by alterations affecting both innate and adaptive immunity.
These results suggest the alterations affecting HB-EGF signaling could comprise a contributing factor in psychiatric disorder.
Ectopic overexpression of TAGL1 resulted in homeotic alterations affecting floral organ identity that were similar to but stronger than those observed in Alq mutant plants.
Even though the above-mentioned pathological alterations affecting neuronal structures are relatively well described, molecular mechanisms underlying DPN remain poorly understood.
In PD, some biochemical alterations affecting neuronal cells have been detected in circulating lymphocytes.
IDHwt gliomas had significantly more chromosome alterations affecting RTK signaling than IDHmut gliomas.
The ER stress response is activated to protect cells from various alterations affecting this organelle.
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