Sentence examples for alteration with high from inspiring English sources

Moreover, a smaller deletion, exons 9 12 del, was identified in a Hispanic survey which is considered as Mexican founder BRCA1 alteration with high frequency (10 12%) [ 97].

Translation of these discoveries into clinical applications requires the development of genomic tests that can reliably detect such somatic alterations with high sensitivity and specificity.

We used OPEN to construct 37 highly active ZFN pairs which induced targeted alterations with high efficiencies (1%–50%) at 11 different target sites located within three endogenous human genes (VEGF-A, HoxB13, and CFTR), an endogenous plant gene (tobacco SuRA), and a chromosomally integrated EGFP reporter gene.

Some loci showed both genetic and epigenetic alterations with high frequencies.

We therefore compared common CN alterations with high frequencies in rectal versus colon cancers.

Recently array-based CGH (A-CGH) on BAC and cDNA microarrays has been used to investigate the genomic alterations with high resolution [ 10- 14].

Recent advances in microarray technology made it possible to screen the genome for chromosomal imbalances (= loss of heterozygosity (LOH) and/or DNA copy number (CN) alterations) with high resolution [ 9- 13].

Using a STZ-mouse model, they demonstrated a reduction in resting heart rate, as well as alterations with high and low frequency power (via spectral analysis of electrocardiograms), in diabetic mice, suggesting a relative reduction of parasympathetic tone.

CN alterations reported in at least 40% of the studies for at least 25% of the study cases were considered to be common CN alterations with high frequencies.> -wrap-foot> tabletablistssthethe published studies on CN alterations in rectal carcinomas used for comparisons with the present study (Nr. 43).

In order to maximize detection accuracy (sensitivity and specificity) in commonly impure clinical specimens, the test was optimized and validated to detect genomic alterations with high accuracy 4. Phosphoprotein analysis was also performed on the FFPE samples using a reversed phase protein microarray (RPMA) platform at a CLIA-certified laboratory (Theranostics Health, Inc., Rockville, MD).

The overall genomic profile of ICC showed many alterations with higher rates for the deletions.