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Three studies [ 22, 24, 26] investigating the effects of resin removal techniques on enamel color alteration were identified.
In addition, a group of metabolic proteins with significant alteration were identified by proteomics, which may suggest the switch of cellular metabolism from tricarboxylic acid cycle to glycolysis.
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No VHL alteration was identified in 3 ccpRCCs studied, as previously described [5].
The 3'-UTR alteration was identified in primary tumor #1218.
However, no transcript alteration was identified at the position described in the DARNED database (figure 1D).
The G→A alteration was identified in 12 of 186 normal controls (6.5%), and the C→T alteration in 10 of 188 normal controls (5.3%).
For each sample in which a base-pair alteration was identified, duplicate PCR reactions were performed to rule out the possibility of PCR-generated artefact.
Of the published genotypes from patients with Morquio A for whom at least one GALNS gene alteration was identified, 48% (257 out of 541) are assessed as being homozygous.
This example illustrates that once a genetic alteration is identified as a driver in one tumor type, infrequent mutations of the same type in the same gene in other tumors can be more reliably interpreted.
Although no specific pattern of alteration was identified, the authors highlighted the fact that Stat1, a transcription activator with a role in mediating the response to interferon, was repressed.
In two of these patients, the alteration was identified on combined T2w-MRC and Gd-EOB-DTPA-enhanced MRC images (false-negative rate, 16%%, P < 0.05; Fig. 2a-c).
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