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From the formula of the aqueous alteration, we found that water and an anhydrous mineral (olivine) are consumed with a mass ratio of 0.1.
When investigating the mechanism of this alteration, we found that the exposure to nanomolar concentrations of beta-amyloid (Aβ) 1-40 peptide was responsible for the increased content of unfolded p53 protein [8].
Nevertheless, this did not influence the alteration we found in the complex-I-dependent respiration.
In addition to observing a checkpoint alteration, we found that normal HMECs with c-Myc overexpression eventually undergo apoptosis, following DNA damage, indicating that deregulated c-Myc sensitises cells to apoptosis.
In a preliminary study of nine septic-shock patients who underwent a brain MRI because of an acute neurologic alteration, we found ischemic stroke and confluent or diffuse white matter lesions (which we called leukoencephalopathy) in two and five patients, respectively [ 7].
Upon addiction of micromolar amounts of Zn2+, the protein undergoes a refolding to the native form and reacquires DNA-binding competence [ 56].Trying to investigate the cause of this alteration we found that the exposure to nanomolar concentrations of the beta-amyloid peptide 1-40 (Aβ 1-40) induced the expression of the unfolded p53 protein isoform in fibroblasts derived from non-AD subjects [ 3].
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Results: of the 28 individuals with clinical alterations, we found 46.4% of DLX and 53.6% of AD.
Finally, none of the alterations we found in primary tumours were previously described in cancers.
It is the case of the most promising alterations we found affecting the EPHA3 and EPHB2 genes in pancreatic adenocarcinoma and AVC samples, considering their emerging role as attractive therapeutic target in cancer [41].
One of the most interesting alterations we found was the insertion occurring in the exon 22 of EGFR that leads to a premature stop codon at aminoacid 896 within the catalytic domain of the protein.
The specific Chr17 alterations we found are detailed in Table 1.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com