Two possibly telomere-protecting alterations are induced: (i) telomerase activity is upregulated by a post-transcriptional mechanism, and (ii) expression of the telomere binding protein TRF2 is upregulated.
Our findings suggest that such alterations are induced by a high-molecular-weight protein/glycoprotein, with possible contributions from a hydrophobic, lipophilic factor.
On a worldwide basis, the absolute majority of HIV infections occur through mucosal surfaces of the genital and intestinal tracts, and the earliest and most dramatic immunologic alterations are induced by the virus in mucosal tissues.
These chemical alterations were induced by exposure to CO2.
It remains to be determined the role of these ASM properties in the onset of childhood asthma and whether specific alterations are induced by the occurrence of obstructive airway diseases in young individuals.
We verified that local treatment with TBHsp70 had a local effect, though it still remains to be determined if any systemic alterations were induced.
Computational models on biological systems have two general purposes: 1) to reproduce what is physiologically observed and understand their biological principles, and 2) to create a platform capable of predicting the cellular phenotype when metabolic alterations are induced in the system.
However, relatively small transcriptome alterations were induced by tetraploidization.
In a fourth cell line, HBEC-3KTR53, both genetic alterations were induced by simultaneous transfection (Sato et al, 2006).
DNA methylation alterations are induced by carcinogenetic factors at the early and precancerous stage in various organs (16 18).
