The phrase "alteration to both" is correct and usable in written English.
It can be used when referring to changes or modifications that affect two entities or items equally.
Example: "The alteration to both the design and functionality of the product has received positive feedback from users."
Alternatives: "change to both" or "modification to both".
Concurrent alteration to both markers, however, produced a 2.81-fold increase in the risk of recurrence (CI 0.94 8.40).
This was associated with a relative risk of 2.67 (CI 0.59 12.01) for alteration to either p53 or p16, and of 15.27 (CI 1.41 165.59) for concurrent alteration to both markers.
In the current study, SEM observations confirmed different degrees of physical damage and morphological alteration to both Gram-positive bacteria and Gram-negative bacteria treated with δ-3-carene, α-asarone, pellitorine, or ciprofloxacin.
After adjusting for grade and stage, the risk ratios for recurrence were 0.45 (CI 0.23 0.88) for a single alteration, and 2.21 (CI 0.68 7.19) for alteration to both markers.
The p16/pRb index was the closest to significance in this cohort, being associated with a relative risk of 1.23 (CI 0.27 5.57) for alteration to either marker, and 5.28 (CI 0.88 31.72) for concurrent alteration to both markers.
We report in particular that our high throughput methods demonstrate that there is a common gene alteration to both tumors (loss of chromosome 1p), which may represent an early event common in the histogenesis of both tumors.
Analysis of the underlying mechanisms revealed that rapamycin increased longevity specifically through the TORC1 branch of the TOR pathway, through alterations to both autophagy and translation.
(III, B) Correct any lipid profile alterations to both slow down the progress of nephropathy and reduce the associated cardiovascular risk.
Rapamycin-mediated life span extension was not associated with alterations in either IIS or AMP-activated protein kinase (AMPK) activity but was blocked by alterations to both autophagy and translation.
Taken together, our results indicate that INPP1 ablation may lead to impairments in glycolytic metabolism and lowering of glucose-derived LPA levels that are the result of transcriptional alterations to both glucose transporters and hexokinase.
This study directly addresses the effect of addition of a CBM to a CD in terms of changes in enzyme activity on insoluble substrate and on alterations to both the surface and bulk properties of non-crystalline cellulose films.
