The phrase "alteration that plays" is grammatically correct and can be used in written English.
It can be used in contexts where you are discussing a change or modification that has an active or dynamic role in a situation or process.
Example: "The alteration that plays a crucial role in the experiment was implemented last week."
Alternatives: "change that operates" or "modification that functions".
Therefore we hypothesized that pancreatic cancer EMT is characterized by specific glycosylation alterations that play functional roles in cancer cell differentiation or migration.
A major challenge in interpreting the data generated by these projects is to distinguish those mutations that play a role in the initiation and progression of cancer, from the much larger number of passenger alterations that play no role in cancer cell development [ 3].
Therefore, quantification of tissue mobility within the thoracolumbar fascia would be an important next step to investigate connective tissue pathophysiological alterations that may play a role in LBP.
To investigate if there was a genomic basis for this effect, we also checked for copy number alterations in genes that play important roles in histone methylation by removing or adding methyl groups to H3K4 (i.e. histone demethylases and methyltransferases).
These alterations commonly affect genes that play important roles in the cell cycle, apoptosis, and DNA repair in non-Hodgkin lymphoma (NHL).
However, it is now established that, after a transient exacerbated proinflammatory response, a counter-regulatory phase develops, rapidly inducing immune alterations that are thought to play a major role in patients' mortality and susceptibility to nosocomial infections.
These morphologic alterations may imply that AQP5 plays a role in epithelial-mesenchymal transition (EMT).
The association between HER-2/neu amplification/overexpression and clinical outcome suggested that the alteration may play a causal role in pathogenesis.
Although the exact molecular mechanism of MA neurotoxicity is still not completely understood, it is clear that developmental alteration must play an important role in mediating the MA-induced effects [ 23].
Perlecan is a critical regulator of growth factor-mediated signaling and angiogenesis, and is fundamental for the maintenance of basement membrane homeostasis [ 59], suggesting that its alteration could play an important role in CRC progression.
