The phrase "alteration that involves" is correct and usable in written English.
It can be used when discussing changes or modifications that require certain actions or elements to be included.
Example: "The alteration that involves changing the color scheme of the website will take place next week."
Alternatives: "modification that includes" or "change that entails".
Indeed, in cBioportal, an arbitrary score is assigned to indicate the amplitude of a genomic alteration that involves the gene of interest, with "0" indicating a diploid status, "1" a low-level copy gain, and "2" a high-level amplification.
Although further studies are still needed to elucidate the complete pathway implicated in the unique aneurysmal phenotype of these mutants, evidence points to a β1-integrin ILK Pinch1 signaling pathway alteration that involves reduced phosphorylation of Smad3.
With respect to the FGM/C characteristics, the majority of women had genital alteration that involved the cutting and removal of portions of the external female genitalia, without stitching, corresponding to either type I or type II.
DNA methylation is the major epigenetic modification that involves alterations of chromatin structure.
We postulate that the development of esophageal adenocarcinoma is accompanied by widespread molecular phenotypic alterations that involve the entire normal squamous esophageal epithelium.
Using this t-statistics, we identified DNA copy number alterations that involved the majority of the chromosomes in both primary tumors and cell lines (Fig. 4).
This nonphysiologic pattern results in postsynaptic alterations that involve gene transcription and the firing pattern of the basal ganglia output neurons.
In addition to direct cytotoxicity, it is suggested that heat triggers a complex pathophysiology that involves alteration of heat shock responses, exaggeration of the acute-phase response, and excessive activation of coagulation [ 1].
Common denominators of TSEs are the lethal neurodegenerative alteration of the CNS that involves spongiform lesions, neuronal loss, gliosis and the accumulation of a conformational abnormal isoform (PrPd) of the physiological prion protein (PrPc) [ 2].
These findings have uncovered a unique mechanism of microbial interaction with host gene expression that involves alterations of miRNA profiles to restrain cell cycling and inhibit colon cancer cell proliferation.
Development of HCC is a multistep process that involves alterations in a number of signaling pathways that synergistically contribute to liver cancer.
