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Somatic mutation rather than a gain of gene copy number of PIK3CA is the frequent genetic alteration that contributes to human breast cancer progression.
The major synaptic alteration that contributes to central sensitization and ongoing pain is when increased activity in one set of synapses results in the facilitation of the activity in another set of synapses [34].
The major synaptic alteration that contributes to central sensitization and ongoing pain is when increased activity in one set of synapses results in the facilitation of the activity in another set of synapses [ 34].
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Major trauma induces metabolic alterations that contribute to the systemic immune suppression in severely injured patients and increase the risk of infection and posttraumatic organ failure.
OSA is associated with both functional and structural vascular alterations that contribute to an increased prevalence of fatal and non-fatal cardiovascular events.
Once identified, conserved chromosomal alterations that contribute to uveal melanoma may reveal the underlying aspects of uveal melanoma onset, metastasis and resistance to current treatment modalities.
This book serves as a single source for the current knowledge on genetic and epigenetic alterations that contribute to the development of drug resistance.
The latter mutations may be "driver" alterations that contribute to tumor progression and malignancy.
In women, primary ovarian sarcomas are exceptionally rare [36], with very little known regarding the molecular alterations that contribute to their development.
In the CHD-fed group the most significant metabolic alterations that contributed to strain separation included increased levels of glucose in C57BL/6, citrate and pyruvate in 129S6, and lactate, lipids and phosphocholine (PC) in C3H (Figure S3).
Despite important findings, only partial understanding of the cellular and molecular processes that may support this life-threatening syndrome has been obtained, and we still lack a comprehensive overview of the complete figure of alterations that contribute to – or reflect – the setting-up of the shock syndrome.
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