Sentence examples for alteration steps from inspiring English sources

An increasing number of studies have demonstrated that multiple genetic alteration steps are associated with malignant progression in PDAC.

However, epigenetic therapy is generally less effective in solid tumors than in hematological malignancies because solid tumor carcinogenesis usually consists of multiple genomic alteration steps.

In its Final Environmental Impact Statement, the Park Service took this alteration one step further by implying causation between the boats and the seals, something Stewart had explicitly ruled out.

In many instances, the novel trait results from multiple genes, which are responsible for different morphological alterations, distinct steps in a novel biochemical cascade, or a combination of both.

We gave more weight to pathways with strong trends in expression patterns (i.e., most genes similarly regulated), alterations in related steps, altered receptors, or groups of genes with broad-reaching effects and to pathways altered by multiple chemicals.

Collectively, these data suggest that compromised insulin secretion in Rfx6-deficient β cells is the consequence, at least in large part, of the combined alteration of key steps in glucose signaling due to a failure of Rfx6 to directly promote the expression of key genes.

With the development of genetically engineered mouse models, it is possible to define the function and dynamics of genetic alterations at discrete steps in carcinogenesis.

These results showed that the delayed life cycle of attB-Ads must be due to alterations in subsequent steps to replication.

Finally, as alterations of various steps in yolk production are also associated with an egg collapse phenotype [32], [33] we tested the localization of the vitellogenin receptor, Yolkless, in mutant egg chambers in order to assess vitellogenin endocytosis.

An alteration in any step during the maturation process could affect miR production.

Genetic and epigenetic alterations are important steps in the development of malignancies and may contribute to disease progression during treatment.