The phrase "alteration so far" is correct and usable in written English.
It can be used to refer to changes or modifications that have occurred up to a certain point in time.
Example: "The alteration so far has improved the overall functionality of the software."
Alternatives: "changes to date" or "modifications thus far".
Probably not enough to make any radical alterations, but so far it's never happened that she's asked for them".
Nevertheless, the brain alterations observed so far in Dyrk1A+/− mice [19], [22] may affect their ability to complete a simple water-escape task requiring swimming and spatial skills, while additional hippocampal related subtle changes might also be implicated in these defects.
The effects of these alterations have so far been interpreted from a promoter-specific viewpoint, focussing on gene gene differences in patterns of histone modifications.
Among several causative alterations identified so far, loss of methylation (LOM) at KvDMR1 and gain of methylation (GOM) at H19DMR are isolated epimutations.
The common molecular genetic alterations identified so far in CCC include mutations in ARID1A and PI3K as well as HNF1B overexpression.
Notably, none of the molecular alterations identified so far have directly impacted patient care and all resulted from candidate gene approaches.
Although the majority of agents that exclusively target amyloid-related alterations have so far been unsuccessful (Corbett et al., 2012), this is likely to be due to insufficient knowledge of single molecular targets and because late interventions are ineffective.
Although β amyloid (Aβ) is thought to play an important role in AD, by triggering a series of processes called the amyloid cascade that finally lead to dementia, the majority of agents that exclusively target amyloid-related alterations have so far been unsuccessful.
Focal amplification of the MET gene, however, is not a common finding in human breast cancer: interphase fluorescence in situ hybridization performed on a human breast cancer tissue microarray did not reveal any amplification of the Met genomic locus [ 65], and this genetic alteration has not so far been reported for BRCA1 mutation carriers.
However, in most of the BWS cases with methylation abnormalities, no DNA sequence alteration has been identified so far.
